Cancer News: Lymphoma/Leukemia

• Older People With Chronic Leukemia May Benefit From Experimental Agent
  The experimental drug ibrutinib (PCI-32765) shows great promise for the treatment of elderly patients with chronic lymphocytic leukemia (CLL), according to interim findings from a clinical trial. The phase I/II trial, co-led by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J...
    Fri, 18 May 2012 01:00:00 PDT
  
  

• Trial Of ALK Inhibitor In Neuroblastoma, Lymphoma
  A pill designed to zero in on abnormal genes that drive specific cancers has produced encouraging early results in children with an uncommon but aggressive type of lymphoma, as well as in children with a rare form of neuroblastoma...
    Fri, 18 May 2012 01:00:00 PDT
  
  

• The Cause Identified Of LGL Leukemia
  LGL leukemia is a relatively rare, malignant blood disease of the mature T-cells and, in many cases, it is related to autoimmune diseases such as rheumatoid arthritis. The pathogenetic mechanism of the disease has been unknown and it has previously been unclear if the disease is an overreaction of the normal defense system or a malignant hematological disease...
    Fri, 18 May 2012 00:00:00 PDT
  
  

• Minimal Residual Disease Detected In Nearly Double The Number Of Leukemia Patients Using High-Throughput Sequencing
  A study led by researchers at Fred Hutchinson Cancer Research Center has found that a next-generation, high-speed DNA-decoding technology called high-throughput sequencing can detect the earliest signs of potential relapse in nearly twice the number of leukemia patients as compared to flow cytometry, the current gold standard for detecting minimal residual disease...
    Fri, 18 May 2012 00:00:00 PDT
  
  

• Using Antioxidants To Stabilize Fanconi Anemia
  Fanconi anemia (FA) is a rare genetic disorder which affects one person in 350,000. People affected by this disease have defects in DNA repair, and are hypersensitive to oxidative damage, resulting in bone marrow failure and an increased predisposition to cancer...
    Thu, 17 May 2012 00:00:00 PDT
  
  

• Specific Clinical Guidance Urgently Needed On Bone Cancer Drugs
  Although bisphosphonate drugs can reduce pain and bone fractures in individuals with multiple myeloma, no one drug is superior, according to a systematic review of the current evidence of these drugs. The review is published in The Cochrane Library. Multiple myeloma is a type of cancer that grows in and on bones. The disease can cause fractures in the spine and long bones...
    Wed, 16 May 2012 10:00:00 PDT
  
  

• After Stem Cell Transplant For Multiple Myeloma Patients, Lenalidomide Prolongs Disease Control
  Multiple myeloma patients are better equipped to halt progression of this blood cancer if treated with lenalidomide, or Revlimid®, following a stem cell transplant, according to a study co-authored by a physician with the Oregon Health & Science University Knight Cancer Institute...
    Wed, 16 May 2012 09:00:00 PDT
  
  

• Clinical Guidance Remains Non-Specific For Drugs To Reduce Bone Cancer Damage
  Bone cancer-related fractures and pain can be reduced by drug treatment, but no one drug is superior, according to a review published in The Cochrane Library. Researchers undertook a systematic review of the current evidence on bisphosphonate drugs, which are used to prevent bone damage in multiple myeloma...
    Wed, 16 May 2012 01:00:00 PDT
  
  

• Revlimid (Lenalidomide) For Myeloma - Phase III Study Findings
  An evaluation of lenalidomide's (Revlimid) long-term 'maintenance' efficacy for patients with multiple myeloma has demonstrated considerable improvements from the time to progression and overall survival for those suffering from this often-fatal form of hematologic cancer. The May 10 issue of the New England Journal of Medicine reports that Dr. Philip L...
    Wed, 16 May 2012 00:00:00 PDT
  
  

• Identification Of A MicroRNA Prognostic Marker In Acute Leukemia
  A study has identified microRNA-3151 as a new independent prognostic marker in certain patients with acute leukemia. The study involves patients with acute myeloid leukemia and normal-looking chromosomes(CN-AML). The study by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J...
    Tue, 15 May 2012 04:00:00 PDT
  
  

• New Maintenance Therapy Benefits Patients With Multiple Myeloma
  Multiple myeloma is a form of cancer where the plasma cells in the bone marrow grow out of control, causing damage to bones as well as predisposing patients to anemia, infection and kidney failure. A medical procedure called autologous hematopoietic stem cell transplantation, commonly known as a stem cell transplant, is frequently an important treatment option for many patients...
    Mon, 14 May 2012 01:00:00 PDT
  
  

• For Patients With Immune Destruction Of Platelets, Rituximab Promotes Long-Term Response
  A new analysis concludes that rituximab, a drug commonly used to treat blood cancers, leads to treatment responses lasting at least five years in approximately one quarter of patients with low platelet counts and a risk of bleeding due to chronic immune thrombocytopenic purpura (ITP)...
    Wed, 09 May 2012 01:00:00 PDT
  
  

• Researcher Finds Pathway Driving Cancer Signals: Protein May Represent A Switch To Turn Off B Cell Lymphoma
  Researchers studying the molecular signals that drive a specific type of lymphoma have discovered a key biological pathway leading to this type of cancer. Cancerous cells have been described as being "addicted" to certain oncogenes (cancer-causing genes), and the new research may lay the groundwork for breaking that addiction and effectively treating aggressive types of B cell lymphoma...
    Wed, 09 May 2012 01:00:00 PDT
  
  

• Decade-Long Study Of HIV Patients Finds Gene Therapy Safe, Lasting
  HIV patients treated with genetically modified T cells remain healthy up to 11 years after initial therapy, researchers from the Perelman School of Medicine at the University of Pennsylvania report in the new issue of Science Translational Medicine...
    Fri, 04 May 2012 00:00:00 PDT
  
  

• For Patients With Multiple Myeloma, Low-Dose Whole-Body CT Finds Disease Missed On Standard Imaging
  Low dose whole body CT is nearly four times better than radiographic skeletal survey, the standard of care in the U.S., for determining the extent of disease in patients with multiple myeloma, a new study shows. The study, conducted at the University of Maryland in Baltimore, included 51 patients who had both a radiographic skeletal survey as well as a low dose whole body CT examination...
    Thu, 03 May 2012 02:00:00 PDT
  
  

• Scientists Use Fruit Flies To Reveal Unknown Function Of A Transcriptional Regulator Of Development And Cancer
  Historically, fly and human Polycomb proteins were considered textbook exemplars of transcriptional repressors, or proteins that silence the process by which DNA gives rise to new proteins. Now, work by a team of researchers at the Stowers Institute for Medical Research challenges that dogma...
    Wed, 02 May 2012 01:00:00 PDT
  
  

• Survival Gap Closes For Young African-American Cancer Patients With Equal Access To Care
  A new analysis from St. Jude Children's Research Hospital adds to evidence that equal access to comprehensive treatment and supportive care typically translates into equally good outcomes for most young African-American and white cancer patients. Researchers found no significant difference in survival rates between African-American and white children treated at St...
    Wed, 02 May 2012 01:00:00 PDT
  
  

• Gene Involved In Fanconi Anemia
  Scientists of KIT and the University of Birmingham have identified relevant new functions of a gene that plays a crucial role in Fanconi anemia, a life-threatening disease. The FANCM gene is known to be important for the stability of the genome. Now, the researchers found that FANCM also plays a key role in the recombination of genetic information during inheritance...
    Wed, 02 May 2012 00:00:00 PDT
  
  

• Lymphoma Therapy Could Deliver A Double Punch
  B cell lymphomas are a group of cancers of that originate in lymphoid tissue from B cells, the specialized immune cell type that produces antibodies. The development of B cell lymphoma is associated with several known genetic changes, including increased expression of MYC, a transcription factor that promotes cell growth and division...
    Wed, 02 May 2012 00:00:00 PDT
  
  

• Protein Vital For Cell Survival And Immune Balance Has Another Form With A Different Function, Could Yield Additional Cancer Treatment Strategy
  Research led by St. Jude Children's Research Hospital investigators suggests that safeguarding cell survival and maintaining a balanced immune system is just the start of the myeloid cell leukemia sequence 1 (MCL1) protein's work...
    Wed, 02 May 2012 00:00:00 PDT
  
  

• Leukaemia Cells Have A Remembrance Of Things Past
  Although people generally talk about "cancer", it is clear that the disease occurs in a bewildering variety of forms. Even single groups of cancers, such as those of the white blood cells, may show widely differing properties...
    Thu, 26 Apr 2012 01:00:00 PDT
  
  

• Prognosis For Patients With Chronic Lymphocytic Leukemia May Be Predicted By New Biomarker
  Researchers at the University of California-San Diego School of Medicine have shown that G protein-coupled receptor expression may predict the prognosis of patients with chronic lymphocytic leukemia. Their findings may identify new ways to treat such patients. The UCSD researchers, led by Paul A. Insel, M.D...
    Thu, 26 Apr 2012 00:00:00 PDT
  
  

• The Anticancer Effects That Come With Breastfeeding May Be Due To High Levels Of TRAIL Protein In Breast Milk
  The benefits of breast milk are well known, but why breastfeeding protects against various forms of cancer remains a mystery. A new study in the Journal of Human Lactation (published by SAGE) found high levels of cancer-fighting TNF-related apoptosis inducing ligand (TRAIL) in human milk, which might be one source of breast milk's anticancer activity...
    Wed, 25 Apr 2012 01:00:00 PDT
  
  

• Researchers Identify A New Trigger For Alternate Reproduction Pathway Of HIV-Related Cancer Virus
  A research team led by Children's National Medical Center has identified a trigger that causes latent Kaposi's sarcoma-associated herpesvirus (KSHV) to rapidly replicate itself. KSHV causes Kaposi's sarcoma, primary effusion lymphoma, and other cancers that commonly affect immunocompromised patients, including those with AIDS...
    Thu, 19 Apr 2012 00:00:00 PDT
  
  

• 'Addiction' Of Leukemia Cells Exploited In New Therapy
  A new study describes a therapeutic approach to halting cancer progression by exploiting a previously unrecognized "addiction" of leukemia cells to specific signaling molecules...
    Tue, 17 Apr 2012 02:00:00 PDT